Exposure to nickel may lead to cancer. Health effects. Note: The health effects are highly dependent on the manner and degree of exposure and on the exact chemical 'species' in which the nickel atoms are present.The allergic effects tend to arise from the Nickel cation Ni ++, but it is not entirely clear which chemical species is reponsible for the carcinogenic effects noted much more commonly in the past. Exposure can harm the lungs, stomach, and kidneys. First, nickel causes essential metal imbalances and severely disrupts enzyme action and regulation. Respiratory Conditions: Exposure to nickel may also cause systemic effects. Certain amounts of nickel are useful to the human body, but too much nickel can be toxic. Workers may be harmed from exposure to nickel. Nickel deficiency has not been reported in people, although it may exist, since nickel deficiency has been seen in animals. Preventing nickel levels in the body from getting too low (nickel deficiency). (9) Once it enters the body, nickel targets a number of organs, including the kidneys, lungs, and liver, and produces multiple toxic effects (9, 13). Nickel has been found to have some adverse systemic effects on the body. About 10% of women and 2% of men are highly sensitive to nickel. Inhalation of nickel also can cause cancer of the lungs, nose and sinuses. Nickel deficiency can cause diseases such as diabetes, anemia, cirrhosis, uremia, renal failure, abnormal metabolism of liver lipids and phospholipids. Cancer: Prolonged exposure to nickel, when seen as an occupational hazard, my result in cancer of nose and throat. Taking trace amounts of nickel in a supplement is effective for preventing nickel deficiency. Nickel is an essential element of the human body, and its content is extremely small in the human body. Metabolism and Absorption of Nickel When nickel enters the body it is distributed to all organs, but mostly in the kidney, bone, and lungs (Samal and Mishra, 2011). If you've been exposed to large amounts of nickel, and believe it to be affecting your health, it is important to take proper measures to get your body back in balance. Chronic noncancer health effects may result from long-term exposure to relatively low concentrations of pollutants. Normally, the immune system defends the body … Nickel, which enters the blood stream is Normally, the adult body contains about 10mg of nickel. A nickel allergy is the body’s adverse immune response when someone comes into contact with a product containing nickel. Some of these toxic symptoms include: The Effects of Nickel on Human Health. If nickel enters the body with nickel contaminated air it is retained in the lungs. Nickel (Ni) is a hard, silvery-white metal that may cause irritation to the skin. Nickel is a common metal that can cause many of these problems. 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